Clinical Significance of Serum Thyroid Hormone Level in Patients with Non-small Cell Lung Cancer before and after Chemotherapy_Chinese Journal of Respiratory and Critical Care Medicine

Authors：

XU Chunhua , YU Like.

Department of Respiratory Medicine, Nanjing Chest Hospital. Nanjing, Jiangsu, 210029, ChinaCorresponding Author: YULi-ke, E-mail: yulike-nanjing@ 163. com;

Corresponding author：

Keywords：

Non-small cell lung cancer; Thyroid hormone; Chemotherapy

DOI：

DOI: 10 . 7507 /1671 -6205 . 20130112

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Objective To investigate the changes of thyroid hormone level in patients with nonsmall cell lung cancer ( NSCLC) before and after chemotherapy and its clinical significance.
Methods 78 cases of NSCLC admitted between January 2009 and December 2011 were recruited in the study. The level of total triiodothyronine ( TT3 ) , total thyroxine ( TF4 ) , free triiodothyronine ( FT3 ) , free thyroxine ( FT4 ) , and thyroid stimulating hormone ( TSH) were measured by radioimmunoassay before and after chemotherapy. 35 normal subjects were recruited as control.
Results The levels of TT3 [ ( 1. 27 ±0. 36) nmol /L vs. ( 2. 62 ±0. 46) nmol /L] and FT3 [ ( 2. 65 ±0. 76) pmol /L vs. ( 3. 79 ±0. 63) pmol /L] in the NSCLC patients were significantly lower than those in the controls ( P lt;0. 05) , while the levels of TT4 , FT4 and TSH were similar to the controls. The level of TT3 and FT3 were correlated with clinical stage ( P lt; 0. 05) , and not with histological grade and pathological type ( P gt;0. 05) . The levels of TT3 and FT3 were remarkably increased in complete remission or partial remission patients after chemotherapy ( P lt; 0. 05) .
Conclusion Thyroid hormone measurement may be useful in the patients condition judgment and therapeutic effect monitoring.

Citation： XU Chunhua,YU Like.. Clinical Significance of Serum Thyroid Hormone Level in Patients with Non-small Cell Lung Cancer before and after Chemotherapy. Chinese Journal of Respiratory and Critical Care Medicine, 2013, 12(5): 465-467. doi: DOI: 10 . 7507 /1671 -6205 . 20130112 Copy

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5.	刘建国, 韩秋菊. 肺癌患者放疗及手术前后血清甲状腺激素的观察. 肿瘤基础与临床, 2006, 19 : 308-309 .
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7.	李德忠. 肺癌患者血清TSGF 和甲状腺激素联合测定的临床意义. 武警医学, 2005, 16: 535 -536.
8.	谢毅娟, 唐彬. 肺癌患者血清甲状腺激素变化的初步研究. 广州医药, 2001 , 32: 8 -9.
9.	廖嘉, 任苏平. 血清甲状腺激素在恶性血液病患者中的变化及临床意义. 中国误诊学杂志, 2002 , 2: 591-592 .
10.	章锐锋, 任振义, 祁明浩, 等. 老年性肺癌和功能正常甲状腺病综合征的关系. 中华结核和呼吸杂志, 2006, 29: 213.

1. 周海英, 谢于鹏. 肺癌与血清甲状腺素水平的关系及其临床意义探讨. 浙江临床医学, 2005, 7: 120 -121.
2. Detterbeck FC, Boffa DJ, Tanoue LT. The new lung cancer staging system. Chest, 2009, 136: 260-271 .
3. Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. J Cancer Inst, 2000, 92: 205-216 .
4. Davis PJ, Davis FB, Mousa SA, et al.Membrane receptor for thyroid hormone: physiologic and pharmacologicimplications. Annu Rev Pharmacol Toxicol, 2011, 51: 99-115.
5. 刘建国, 韩秋菊. 肺癌患者放疗及手术前后血清甲状腺激素的观察. 肿瘤基础与临床, 2006, 19 : 308-309 .
6. 杨向红, 孙仁华, 徐云祥, 等. 危重病患者血清甲状腺素和细胞因子变化的研究. 中国急救医学, 2003, 23: 39-40.
7. 李德忠. 肺癌患者血清TSGF 和甲状腺激素联合测定的临床意义. 武警医学, 2005, 16: 535 -536.
8. 谢毅娟, 唐彬. 肺癌患者血清甲状腺激素变化的初步研究. 广州医药, 2001 , 32: 8 -9.
9. 廖嘉, 任苏平. 血清甲状腺激素在恶性血液病患者中的变化及临床意义. 中国误诊学杂志, 2002 , 2: 591-592 .
10. 章锐锋, 任振义, 祁明浩, 等. 老年性肺癌和功能正常甲状腺病综合征的关系. 中华结核和呼吸杂志, 2006, 29: 213.

Chinese Journal of Respiratory and Critical Care Medicine

Clinical Significance of Serum Thyroid Hormone Level in Patients with Non-small Cell Lung Cancer before and after Chemotherapy

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